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Straumann, A, Hoesli, S, Bussmann, C, Stuck, M, Perkins, M, Collins, LP, Payton, M, Pettipher, R, Hunter, M, Steiner, J & Simon, HU. (2013). Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy, 68, 375-385.
Singh, D, Cadden, P, Hunter, M, Collins, LP, Perkins, M, Pettipher, R, Townsend, E, Vinall, S & O’Connor, B. (2013). Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459. Eur Respir J. 41:46-52.
Horak, F, Zieglmayer, P, Zieglmayer, R, Lemell, P, Collins, LP, Hunter, MG, Steiner, J, Lewis, T, Payton, MA, Perkins, CM & Pettipher, R. (2012). The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. Allergy, 67, 1572-1579.
Barnes, N, Pavord, I, Chuchalin, A, Bell, J, Hunter, M, Lewis, T, Parker, D, Payton, M, Collins, LP, Pettipher, R, Steiner, J & Perkins, CM. (2012). A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma. Clin Exp Allergy, 42, 38-48.
Pettipher, R, Vinall, SL, Xue, L, Speight, G, Townsend, ER, Gazi, L, Whelan, CJ, Armer, RE, Payton, MA & Hunter, MG. (2012). Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils. J Pharmacol Exp Ther, 340, 473-482. PDF
Pettipher, R & Whittaker, M. (2012). Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis. J Med Chem, 55, 2915-2931.
Xue, L, Barrow, A & Pettipher, R. (2009). Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on TH2 cells mediates cytokine production by TH2 lymphocytes in response to activated mast cells. Clin Exp Immunol, 156, 126-133. PDF
Xue, L, Barrow, A & Pettipher, R. (2009). Novel function of CRTH2 in preventing apoptosis of human TH2 cells through activation of the phosphatidylinositol 3-kinase pathway. J Immunol, 182, 7580-7586. PDF
Pettipher, R. (2008). The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br J Pharmacol, 153 Suppl 1, S191-S199. PDF
Pettipher, R, Hansel, TT & Armer, R. (2007). Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov, 6, 313-325.
Gyles, SL, Xue, L, Townsend, ER, Wettey, F & Pettipher, R. (2006). A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ TH2 lymphocytes in response to mast cell supernatants. Immunology, 119, 362-368.
Xue, L, Gyles, SL, Wettey, FR, Gazi, L, Townsend, E, Hunter, MG & Pettipher, R. (2005). Prostaglandin D2 causes preferential induction of proinflammatory TH2 cytokine production through an action on chemoattractant receptor-like molecule expressed on TH2 cells. J Immunol, 175, 6531-6536. PDF