Publications

  1. Pettipher R, Hunter MG, Perkins CM, Collins LP, Lewis T, Baillet M, Steiner J, Bell J, Payton MA (2014). Heightened response of eosinophilic asthmatic patients to the CRTH2 antagonist OC000459. Allergy, 69, 1223-1232.
  2. Straumann, A, Hoesli, S, Bussmann, C, Stuck, M, Perkins, M, Collins, LP, Payton, M, Pettipher, R, Hunter, M, Steiner, J & Simon, HU. (2013). Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy, 68, 375-385.
  3. Singh, D, Cadden, P, Hunter, M, Collins, LP, Perkins, M, Pettipher, R, Townsend, E, Vinall, S & O’Connor, B. (2013). Inhibition of the asthmatic allergen challenge response by the CRTH2 antagonist OC000459. Eur Respir J. 41:46-52.
  4. Horak, F, Zieglmayer, P, Zieglmayer, R, Lemell, P, Collins, LP, Hunter, MG, Steiner, J, Lewis, T, Payton, MA, Perkins, CM & Pettipher, R. (2012). The CRTH2 antagonist OC000459 reduces nasal and ocular symptoms in allergic subjects exposed to grass pollen, a randomised, placebo-controlled, double-blind trial. Allergy, 67, 1572-1579.
  5. Barnes, N, Pavord, I, Chuchalin, A, Bell, J, Hunter, M, Lewis, T, Parker, D, Payton, M, Collins, LP, Pettipher, R, Steiner, J & Perkins, CM. (2012). A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma. Clin Exp Allergy, 42, 38-48.
  6. Pettipher, R, Vinall, SL, Xue, L, Speight, G, Townsend, ER, Gazi, L, Whelan, CJ, Armer, RE, Payton, MA & Hunter, MG. (2012). Pharmacologic Profile of OC000459, a Potent, Selective, and Orally Active D Prostanoid Receptor 2 Antagonist That Inhibits Mast Cell-Dependent Activation of T Helper 2 Lymphocytes and Eosinophils. J Pharmacol Exp Ther, 340, 473-482. PDF
  7. Pettipher, R & Whittaker, M. (2012). Update on the development of antagonists of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2). From lead optimization to clinical proof-of-concept in asthma and allergic rhinitis. J Med Chem, 55, 2915-2931.
  8. Xue, L, Barrow, A & Pettipher, R. (2009). Interaction between prostaglandin D and chemoattractant receptor-homologous molecule expressed on TH2 cells mediates cytokine production by TH2 lymphocytes in response to activated mast cells. Clin Exp Immunol, 156, 126-133. PDF
  9. Xue, L, Barrow, A & Pettipher, R. (2009). Novel function of CRTH2 in preventing apoptosis of human TH2 cells through activation of the phosphatidylinositol 3-kinase pathway. J Immunol, 182, 7580-7586. PDF
  10. Pettipher, R. (2008). The roles of the prostaglandin D(2) receptors DP(1) and CRTH2 in promoting allergic responses. Br J Pharmacol, 153 Suppl 1, S191-S199. PDF
  11. Pettipher, R, Hansel, TT & Armer, R. (2007). Antagonism of the prostaglandin D2 receptors DP1 and CRTH2 as an approach to treat allergic diseases. Nat Rev Drug Discov, 6, 313-325.
  12. Gyles, SL, Xue, L, Townsend, ER, Wettey, F & Pettipher, R. (2006). A dominant role for chemoattractant receptor-homologous molecule expressed on T helper type 2 (Th2) cells (CRTH2) in mediating chemotaxis of CRTH2+ CD4+ TH2 lymphocytes in response to mast cell supernatants. Immunology, 119, 362-368.
  13. Xue, L, Gyles, SL, Wettey, FR, Gazi, L, Townsend, E, Hunter, MG & Pettipher, R. (2005). Prostaglandin D2 causes preferential induction of proinflammatory TH2 cytokine production through an action on chemoattractant receptor-like molecule expressed on TH2 cells. J Immunol, 175, 6531-6536. PDF