CRTH2 Biology
The CRTH2 receptor and its role in allergy

CRTH2 is a G protein coupled receptor. It is of interest as a target for drugs that treat allergic disease for the following reasons:

  • It is selectively expressed by the key effector cell types mediating allergic responses – Th2 lymphocytes, type 2 innate lymphoid cells (ILCs), basophils and eosinophils
  • CRTH2 is specifically activated by prostaglandin D2, an abundant lipid product of activated mast cells.
  • Mast cell dependent activation of Th2 lymphocytes, type 2 ILCs and eosinophils is blocked by CRTH2 antagonists
  • The prostaglandin D2/CRTH2 pathway is known to be upregulated in severe eosinophilic asthma, and implicated in the pathogenesis of atopic dermatitis

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